high pressure signs = flattened primers (no round edges anymore), shiny spot on the bolt face on certain rifles, stiff extraction, measuring case heads (I never do it), etc
if you cross reference a bunch of data for the particular cartridge/bullet weight/powder combo, find an average max load, reduce it by 6% or so, and work up in .5 grain increments, you'll probably not encounter any of these signs until you're close to the max. Using a chronograph is a good way to gauge pressure (velocity is a by product of pressure). If you're seeing #s above what the manuals say, you're probably pushing the envelope too much, and should back off a bit.
I load my rifles so they match factory ammo velocity, and have no pressure problems. Use a powder ideal for the application, and you should be fine.
Safety first!